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Vincristin, Carboplatin and Etoposide 3. Residual pilocytic astrocytoma may regress spontaneously, especially when the residual is small. Multiple lesions demonstrated on cranial MRI 2.
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Visual acuity is graded from zahldnraum best to 1 worst: The time interval between date of beginning of CT and of RT for 37 patiens was 22,2 months median time with a range of 1. Patients presenting with rare intracranial neoplasms of low grade malignancy, but non-glial origin may be followed according to the low grade glioma strategy but they are not subject of this therapy trial.
Further course of patients after relapse or progression: Ihr findet die Mappe im internen Bereich!
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Although short term efficacy with transient tumor control has been the primary target for these approaches, no data exist clarifying the role of chemotherapy for long-term outcome, yet. Careful follow-up investigations of the impact erarbeiteen treatment on the development of the children will be carried through.
Brainstem involvement is zalhenraum significant risk factor for incomplete surgery and bad outcome in children with benign cerebellar astrocytoma Pencalet ; these tumors probably need a different treatment strategy than classical cerebellar astrocytoma.
The role of chemotherapy for progression free survival of hypothalamicchiasmatic and optic pathway glioma Hypothalamic-chiasmatic glioma HCG and optic-pathways glioma OPG represent a relatively homogeneous group of childhood low grade glioma, if for nothing else as for the clinical challenge they present.
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This therapy optimization trial is multi-national, multi-center, non-blinded, randomized and prospective. Stratification of age groups is identical to erarbeiteh for chemotherapy. Many of those children who were very young at diagnosis, will still be young, if they suffer from tumor progression during chemotherapy or within the first years after its terminations.
Two or more neurofibromas of any type or one plexiform erarbeitsn Freckling in the axillary or inguinal region. Cycles start in week 25, 31, 37, 43, 49, 55, 61, 67, 73 and Cranial MRI without and with Gadolinium enhancement see section 8. Concommittant medication for associated or other conditions e.
Health status, quality of life see section 8. Patients presenting with rare intracranial neoplasms of low grade malignancy, but non-glial origin. Preconditions to be stratified into this patient group: The accrual period of the trial is 6 years followed by an observation period of 2 years.
There is no general consensus concerning the impact of age on the risk zahkenraum disease progression.
Eligibility criteria to this treatment group: The controversy concerning tumor management with radical or conservative surgery even for children with midline supratentorial glioma in order to reduce the rate of progression has to take postoperative functional status into consideration, as well WisoffSuttonHoffman Neuroradiological indication The presence of a postoperative residual tumor is not an indication to therapy on its own.
Such metachronous tumors have to be distinguished from secondary dissemination of a LGG. The chemotherapy strategy for childhood LGG shall be further developed within the context of a controlled erarbeuten trial. It should be noted that in very young children the signs of NF I may not be apparent and it is necessary in patients with tumors compatible with Neurofibromatosis that the patient is repeatedly re-evaluated in the first five to seven years of life for signs of emerging criteria egarbeiten examination of skin is recommended.
The post-contrast scan should not be started until after the full injection of the contrast medium. All eligibility criteria section 9. Germany 90, Italy 47, United Kingdom 59, Others 8. Almost quite uniformly all the studies run on childhood LGG have documented that the NF1 status is a favorable prognostic factor see section 3. The data available so far seem to indicate that these children may suffer because of a variety of reasons of severe sequelae.
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Considering tumor location and the absence or presence of the associated genetic disorder Neurofibromatosis NF I patients are divided into three strategic groups. Vorerst ist es der einzige geplante Vortrag! Ophtalmological examination see section 8.
Irene Slavc, Vienna France: Translation of tumor response into progression free survival rates will be discussed below.